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. 2021 Sep 6;11:754146. doi: 10.3389/fonc.2021.754146

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Copyright © 2021 Xu, Chen, Shen, Yang, Peng, Tong and Fu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Circ_0013587 expression is down-regulated in erlotinib-resistant AsPC-1 cells. (A) Effect of erlotinib treatment (48 h) on the survival of erlotinib-sensitive AsPC-1 cells and erlotinib-resistant AsPC-1/Erlo cells was analyzed using CCK-8 assay. (B) The qRT-PCR assay showed significant down-regulation of circ_0013587 expression in AsPC-1/Erlo cells than in AsPc-1 cells. (C) qRT-PCR analysis of circ_0013587 levels in pancreatic cancer (PC) and adjacent normal tissues. (D) qRT-PCR analysis of circ_0013587 expression in four pancreatic cancer cell lines and a normal pancreatic cell line HPDE6-C7. (E–G) The expression of circ_0013587 in pancreatic cancer patients with different tumor stages (E), different tumor grades (F), and patients with (or without) lymph node metastasis (G). (H) Kaplan-Meier analysis of overall survival in pancreatic cancer patients with high (above median) versus low (below median) circ_0013587 levels. **P < 0.01, ***P < 0.001.