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Circ_0013587 mediates erlotinib resistance through regulating miR-1227 expression. (A, B) AsPC-1/Erlo (A) and AsPC-1 (B) cells transfected as indicated were exposed to each concentration of erlotinib for 48 h, and the inhibitory effects of erlotinib were evaluated using CCK-8 assays. (C, D) Pancreatic cancer cells were transfected as indicated and cell invasion was measured using transwell invasion assays. ***P < 0.001.
