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. 2021 Sep 6;11:754146. doi: 10.3389/fonc.2021.754146

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Copyright © 2021 Xu, Chen, Shen, Yang, Peng, Tong and Fu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MiR-1227 promotes erlotinib resistance and cell invasion via reducing E-cadherin expression. (A, B) Western blot analysis of E-cadherin, Twist, and Vimentin in AsPC-1 (A) and AsPC-1/Erlo (B) cells transfected as indicated. (C) AsPC-1/Erlo cells transfected as indicated were exposed to each concentration of erlotinib for 48 h, and the inhibitory effects of erlotinib were evaluated using CCK-8 assays. (D) AsPC-1/Erlo cells were transfected as indicated, and cell invasion was evaluated using cell invasion assays. (E) AsPC-1 cells transfected as indicated were exposed to each concentration of erlotinib for 48 h, and the inhibitory effects of erlotinib were evaluated using CCK-8 assays. (F) AsPC-1 cells were transfected as indicated, and cell invasion was evaluated using cell invasion assays. ***P < 0.001.