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. 2021 Sep 6;11:754146. doi: 10.3389/fonc.2021.754146

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Copyright © 2021 Xu, Chen, Shen, Yang, Peng, Tong and Fu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overexpression of circ_0013587 reverses erlotinib resistance in pancreatic cancer in vivo. (A) Mice were injected with AsPC-1/Erlo cells stably expressing circ_0013587 or AsPC-1/Erlo control cells and were treated with erlotinib. Tumor growth was measured every 5 days to draw the growth curve. (B) Tumor weight was recorded for each derived xenograft tumor. (C) A schematic model showing that circ_0013587 reverses erlotinib resistance in pancreatic cancer cells by regulating the miR-1227/E-cadherin pathway. ***P < 0.001.