Table 3B.

Association of systolic and diastolic blood pressure change (mmHg) with respect to sodium bicarbonate dose (mg/kg body weight).

		Regression models
		Crude		Adjusted I		Adjusted II
	n	β	95% CI	β	95% CI	β	95% CI
Δ 24h-ABPM	43
Systolic		0.047	−0.022 to 0.116	0.047	−0.023 to 0.117	0.047	−0.026 to 0.119
Diastolic		0.021	−0.026 to 0.068	0.021	−0.026 to 0.068	0.023	−0.026 to 0.071
Δ Daytime-ABPM	43
Systolic		0.046	−0.028 to 0.119	0.045	−0.03 to 0.12	0.046	−0.033 to 0.122
Diastolic		0.013	−0.036 to 0.062	0.013	−0.036 to 0.063	0.015	−0.036 to 0.066
Δ Nighttime-ABPM	37
Systolic		0.044	−0.037 to 0.124	0.044	−0.038 to 0.125	0.049	−0.036 to 0.133
Diastolic		0.026	−0.027 to 0.079	0.026	−0.025 to 0.077	0.022	−0.030 to 0.075
Δ Office BP	45
Systolic		−0.024	−0.161 to 0.112	−0.024	−0.163 to 0.114	−0.036	−0.183 to 0.11
Diastolic		−0.067	−0.15 to 0.016	−0.067	−0.151 to 0.017	−0.068	−0.157 to 0.022

Crude, sodium bicarbonate dose (mg /kg body weight).

Adjusted I, Crude + change of eGFR from baseline to week 8 (mL/min per 1.73 m²).

Adjusted II, Adjusted I + increase and decrease of antihypertensive medication vs. no change of antihypertensive medication.

24h-ABPM, 24 h ambulatory blood pressure monitoring; Daytime ABPM, from 8:00 until 22:00 ambulatory blood pressure monitoring; Nighttime ABPM, from 22:01 until 7:59 ambulatory blood pressure monitoring; Office BP, office blood pressure measurement; β, point estimate (mmHg); 95% CI, 95 % confidence interval.