Table 3C.

Association of systolic and diastolic blood pressure change (mmHg) with respect to treatment category (low, moderate, high; reference, none).

Treatment category		Crude				Adjusted I				Adjusted II
		Systolic		Diastolic		Systolic		Diastolic		Systolic		Diastolic
	n	β	95% CI	β	95% CI	β	95% CI	β	95% CI	β	95% CI	β	95% CI
24h-ABPM
Low	15	2.316	−4.095 to 8.726	−0.63	−4.953 to 3.693	2.21	−4.332 to 8.752	−0.601	−5.016 to 3.814	2.212	−4.515 to 8.939	−0.55	−5.08 to 3.98
Moderate	8	5.589	−1.914 to 13.092	1.852	−3.209 to 6.912	5.534	−2.074 to 13.142	1.867	−3.268 to 7.0	5.706	−2.331 to 13.744	1.908	−3.504 to 7.32
High	9	3.722	−3.536 to 10.98	0.948	−3.947 to 5.843	3.654	−3.712 to 11.02	0.966	−4.005 to 5.938	3.607	−4.016 to 11.231	1.108	−4.025 to 6.242
Daytime-ABPM
Low	15	1.972	−4.919 to 8.862	−1.387	−5.915 to 3.141	1.785	−5.238 to 8.807	−1.246	−5.858 to 3.366	1.764	−5.437 to 8.965	−1.177	−5.902 to 3.548
Moderate	8	4.064	−4.001 to 12.13	0.404	−4.896 to 5.705	3.966	−4.201 to 12.132	0.479	−4.885 to 5.842	4.351	−4.254 to 12.955	0.617	−5.029 to 6.262
High	9	3.951	−3.851 to 11.753	0.177	−4.95 to 5.304	3.832	−4.076 to 11.739	0.267	−4.925 to 5.46	3.652	−4.509 to 11.813	0.433	−4.922 to 5.787
Nighttime-ABPM
Low	14	−0.495	−7.143 to 6.150	−3.920	−8.003 to 0.162	−0.336	−7.110 to 6.438	−3.540	−7.538 to 0.458	−0.262	−7.153 to 6.628	−3.579	−7.648 to 0.491
Moderate	6	5.728	−2.645 to 14.102	1.860	−3.28 to 7.003	5.748	−2.733 to 14.229	1.908	−3.073 to 6.914	6.083	−2.672 to 14.839	1.739	−3.431 to 6.910
High	6	1.492	−6.881 to 9.866	0.150	−4.992 to 5.293	1.588	−6.050 to 10.080	0.378	−4.638 to 5.390	2.255	−6.482 to 10.981	−0.112	−5.171 to 5.148
Office BP
Low	15	4.65	−7.425 to 16.725	−0.517	−7.847 to 6.813	4.645	−7.653 to 16.942	−0.311	−7.752 to 7.131	4.507	−8.053 to 17.067	−0.29	−7.906 to 7.327
Moderate	10	−0.217	−13.567 to 13.133	−6.283	−14.387 to 1.82	−0.219	−13.744 to 13.307	−6.205	−14.389 to 1.979	−1.139	15.431 to 13.153	−6.567	−15.233 to 2.1
High	8	−0.042	−14.273 to 14.189	−4.708	−13.347 to 3.93	−0.044	14.467 to 14.379	−4.606	−13.333 to 4.122	−0.96	−15.955 to 14.035	−4.616	−13.71 to 4.477

Crude, treatment category of sodium bicarbonate: low (1–37.9 mg/kg/day), moderate (38–79.9 mg/kg/day), and high (≥80 mg/kg/day) vs. no treatment (reference); Adjusted I, Crude + change of eGFR from baseline to week 8 (mL/min per 1.73 m²); Adjusted II, Adjusted I + increase and decrease of antihypertensive medication vs. no change of antihypertensive medication.

24h-ABPM, 24 h ambulatory blood pressure monitoring; Daytime ABPM, from 8:00 until 22:00 ambulatory blood pressure monitoring; Nighttime ABPM, from 22:01 until 7:59 ambulatory blood pressure monitoring; Office BP, office blood pressure measurement; β, point estimate (mmHg); 95% CI, 95 % confidence interval.