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. 2021 Sep 6;12:730070. doi: 10.3389/fimmu.2021.730070

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Copyright © 2021 Sun, Sun, Li, Qian, Zhang, Huang, Shen, Law, Liu and Gu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interleukin-6 (IL-6) induces skeletal muscle atrophy. (A) Laminin immunohistochemical staining of the tibialis anterior muscle of mice in the control group (injected with phosphate-buffered saline); scale bars = 20 μm. (B) Laminin immunohistochemical staining of the tibialis anterior muscle. (C) Results of the skeletal muscle wet-weight ratio between the experimental group and the control group. (D) Results of the comparison of the cross-sectional muscle fiber area between the experimental group and the control group. Statistical results, the bar graph represents the mean ± standard error of the mean, T-test was used to calculate the P-values, n = 3, **P < 0.01, ***P < 0.001, experimental group vs. control group. CSA, cross-sectional area; Ctrl, control; IL-6, interleukin-6; rIL-6, recombinant interleukin-6.