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. 2021 Sep 6;12:730070. doi: 10.3389/fimmu.2021.730070

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Copyright © 2021 Sun, Sun, Li, Qian, Zhang, Huang, Shen, Law, Liu and Gu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of differentially expressed genes (DEGs) in skeletal muscle after interleukin-6 (IL-6) infusion. (A) A summary of the number of DEGs after one and three days of IL-6 infusion in the intervention group compared with the control group. Blue indicates up-regulated genes, and orange indicates down-regulated genes. (B, C) Heat maps of all differentially expressed genes after one day (B) and three days (C) of IL-6 infusion. Red indicates up-regulated expression, and blue indicates down-regulated expression. (D) Principal component analysis of a single-sequencing sample. The shorter the sample clustering distance, the more similar the samples. The control group is marked by a blue ellipse and the experimental group by a green ellipse. (E) VENNY diagram of the overlap of DEGs after one and three days of IL-6 infusion. IL-6, interleukin-6; PBS, phosphate-buffered saline.