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. 2021 Sep 6;12:730070. doi: 10.3389/fimmu.2021.730070

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Copyright © 2021 Sun, Sun, Li, Qian, Zhang, Huang, Shen, Law, Liu and Gu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biological functions of newly discovered differentially expressed genes (DEGs) after three days of interleukin-6 (IL-6) infusion. (A) The number of DEGs that were newly discovered after three days of IL-6 infusion. Blue indicates up-regulated genes, and orange indicates down-regulated genes. (B) The GO analysis results of up-regulated and down-regulated DEGs according to the biological process. (C) The GO analysis results of the up-regulated and down-regulated DEGs according to the cell component. (D) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of the up-regulated and down-regulated DEGs. The top 10 GO or KEGG terms are displayed. ATP, adenosine triphosphate; up, up-regulated.