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. 2021 Sep 6;12:730070. doi: 10.3389/fimmu.2021.730070

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Copyright © 2021 Sun, Sun, Li, Qian, Zhang, Huang, Shen, Law, Liu and Gu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interaction between newly discovered differentially expressed genes (DEGs) and differentially expressed transcription factors (DETFs) after three days of interleukin-6 (IL-6) infusion. All the newly discovered DEGs and DETFs after three days of IL-6 infusion are integrated and analyzed. The three representative transcription factors (TFs) marked can interact strongly with IL-6 or have been reported to be related to skeletal muscle atrophy. Only TFs and DEGs with a score > 200 for the interaction are shown.