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. 2021 Sep 6;11:698980. doi: 10.3389/fonc.2021.698980

Table 2.

Univariable Cox regression model analyses of OS for nomogram.

Characteristics OR Univariable analysis p value
95% CI lower 95% CI upper
AGE
 ≤65y reference
 >65y 1.308 0.884 1.934 0.181
DFAC
 0 reference
 1 0.640 0.390 1.050 0.079
 2 0.657 0.286 1.510 0.325
Child-Pugh
 A reference
 B 1.473 0.905 2.397 0.121
 C 2.539 0.080 4.228 0.593
CV
 <50 reference
 50-100 <0.001 <0.0001 <0.0001 0.953
 >100 0.650 0.433 0.976 0.038**
NHG
 1 reference
 2 1.220 0.650 2.288 0.538
 3 1.224 0.640 2.342 0.544
 4 1.350 0.434 4.197 0.606
PLT
 <100 reference
 100-300 1.405 0.809 2.439 0.229
 >300 1.459 0.631 3.374 0.379
VASTP
 None reference
 Micro 0.879 0.538 1.436 0.608
 Macro 1.933 0.886 4.216 0.099
P-STAGE
 1 reference
 2 1.080 0.636 1.835 0.777
 3 2.318 1.499 3.585 <0.001**
 4 7.824 1.884 32.502 0.005**
BMI
 <18.5 reference
 18.5-23.9 0.976 0.654 1.458 0.906
 >23.9 0.555 0.272 1.129 0.106
RT
 R0 reference
 R1 0.969 0.308 3.048 0.957
 R2 2.791 1.211 6.430 0.017**
VHS
 None reference
 HBV 0.607 0.367 1.004 0.053
 HCV 1.205 0.578 2.515 0.620
 HBV+HCV 1.873 1.107 3.169 0.020**
CFDR
 None reference
 Yes 1.339 0.896 2.000 0.157
ALB
 <3.5g/dl reference
 >3.5g/dl 1.435 0.725 2.840 0.303
TB
 <1.4mg/dl reference
 >1.4mg/dl 1.066 0.435 2.613 0.889
AFP
 ≤25 reference
 25-400 1.289 0.724 2.293 0.391
 >400 3.646 2.485 5.351 <0.001**
THCR
 None reference
 Yes 0.919 0.478 1.768 0.802
PTS
 None reference
 Yes 2.129 1.436 3.158 <0.001**
POT
 None reference
 Yes 1.180 0.701 1.988 0.535
RFCH
 None reference
 Yes 1.351 0.907 2.014 0.141
Gender
 Female reference
 Male 1.044 0.695 1.569 0.838
OM
 None reference
 Yes 1.279 0.861 1.898 0.225
TNM
 I reference
 II 2.200 1.374 3.521 0.001**
 III 2.871 1.761 4.682 <0.001**
 IV 3.237 1.272 8.238 0.014**

OR, Odds ratio; CI, confidence interval; **, It is statistically significant and included in the multivariate COX regression analysis. DFAC, degree of inflammation adjacent to the cancer; Child-Pugh, Child pneumonia classification grade; CV, creatinine value; NHG, tumor histology grade; PLT, platelet count; VASTP, vascular tumor cell type; P.STAGE, pathological stage; BMI, body mass index; RT, resection marginal residual tumor; VHS, viral hepatitis serology; CFDR, first-degree relative hepatocellular carcinoma; ALB, albumin; TB, total bilirubin; AFP, alpha-fetoprotein; THCR, risk factors; PTS, patients Tumor status; POT, postoperative treatment; RFCH, relative family cancer history; OM, other malignant tumors, TNM, tumor node metastasis.