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. 2021 Sep 6;12:715582. doi: 10.3389/fimmu.2021.715582

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Copyright © 2021 Wang, Kang, Yang, Zhang, Li and Zheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ASFV replication (9). ASFV first replicates briefly in the nucleus (I), and then the cytoplasm (II). p37 mediates the nucleocytoplasmic transport of ASFV genome. In addition, p10 and p14 can also enter the nucleus. ASFV replication in the nucleus ruptures the nucleolus and nuclear membrane, thus collapsing laminin A/C and recruiting the nucleoporin p62 to the periphery. ASFV produces short DNA fragments the nucleus and long fragments in the cytoplasm. pP1192R catalyzes transient nick generation in double-stranded DNA and promotes the translation process. To prevent active oxygen-mediated damaged DNA from interfering with replication, ASFV also uses BER to repair the damaged DNA (III).