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. 2021 Sep 6;12:715582. doi: 10.3389/fimmu.2021.715582

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Copyright © 2021 Wang, Kang, Yang, Zhang, Li and Zheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ASFV translation and post-translational modification (39). (1) ASFV promotes viral gene expression by maintaining the host histone H3 K9/K14 in a low acylation state. (2) EP424R-encoded FTS-J-like RNA methyl transferase may stabilize rRNA in cells and prevent protein synthesis shut down. (3) pD250R inhibits viral translation by reducing the number of transcripts. (4) The virus protein DP71L binds to host phosphatase 1 (PP1) to form eIF2 alpha dephosphorylation, thus enhancing viral protein synthesis. (5) ASFV IAP homologous protein A224L inhibits the Caspase-3-mediated eIF4G degradation to promote translation. (6) ASFV promotes mTOR-mediated eIF4G phosphorylation and Mnk-1-mediated eIF4E phosphorylation to enhance protein synthesis. (7) ASFV promotes 4E-BP phosphorylation and viral protein translation in the early stage of infection, while (8) promotes 4E-BP dephosphorylation in the late stage to inhibit translation.