Table 1.
African swine fever virus (ASFV) regulates inflammation through regulating proinflammatory cytokines, inflammatory mediators, ALR and NF-κB pathway.
| Regulation pathway | Viral protein | Target molecule | Effect |
|---|---|---|---|
| proinflammatory cytokines | pL83L (71, 72) | interact with IL-1β | / |
| inflammatory mediator | pA238L (71, 73–75) | inhibit p300 | inhibit NO |
| inhibit TNF-α | inhibit prostaglandin | ||
| ALR | pS183L、pE199L、pO61R、pI7L (71, 75) | / | Activate AIM2 inflammasome |
| pI226L、pA151R、pNP419、pQP383R (75) | / | inhibit AIM2 inflammasome | |
| NF-κB | pA238L (71, 73, 74) | inhibit p300/CBP | inhibit p65 acetylation and NF-κB |
| binding with p65 | inhibit the nuclear transport of NF-κB | ||
| promoting p65 nuclear exporting | |||
| MGF-360-12L protein (76) | inhibit the interaction between p65 and importin α | ||
| inhibit the interaction between NF-κB andnuclear transport proteins |