Table 3.

miRNAs and germinal BRCA mutations.

miRNA role/function	Identified miRNAs	miRNA detection tissue	Reference
Upregulated by wild-type BRCA1	miR-182; miR-146-5p; miR-15a; miR-16; miR-638; miR-17	Tumor/normal tissue/serum	(19)
Downregulated by wild-type BRCA1	miR-148; miR-152; miR-205; miR-99; miR-146a	Tumor/normal tissue/serum	(19, 72)
Combined expressions of miRNAs distinguish between BRCA-mutated and BRCA wild-type BC	miR-142-3p; miR-505; miR-1248; miR-181a-2; miR-25; miR-340	Tumor/normal tissue	(72)
	miR-627; miR-99b; miR-539; miR-24; miR-331; miR-663a; miR-362; miR-145	Tumor/normal tissue	(73)
Downregulated in BRCA-mutated BC	miR-155; let-7a; miR-335	Tumor tissue	(27, 29, 61)
	miR-200c	Cell culture	(74)
Overexpressed in BRCA-mutated BC	miR-3665; miR-3960; miR-4417; miR-4498; let-7	Tumor tissue	(75)
Regulate BRCA1 expression in BC	miR-342; miR-182; miR-335; miR-146a, miR-146b-5p; miR-182	Tumor tissue	(26, 28, 60, 76)
Restores HRR and genomic stability in BRCA2-mutated cancers	miR-493-5p	Tumor tissue	(77)

miRNA, microRNA; BC, breast cancer; HRR, Homologous Recombination Repair.