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Flowchart of the study. TARGET: therapeutically applicable research to generate effective treatments; OS, osteosarcoma; DEGs, differentially expressed genes; LASSO, least absolute shrinkage and selection operator Cox regression model; AUC, area under the ROC curve; IAUC, integrated AUC; ROC, receiver operating characteristic; IBS, integrated Brier score; GSEA, Gene Set Enrichment Analysis; TICs, tumor-infiltrating immune cells.
