Table 1.
Clinical characteristics and endocrine profiles of insulin resistant (IR) and non-insulin resistant infertile women (Non-IR).
| Non-IR (lean) (n = 97) | IR (lean) (n = 58) | P-value | |
|---|---|---|---|
| Age (years) | 31.43 ± 4.56 | 30.67 ± 4.65 | 0.320 |
| Antral follicle number | 12.60 ± 6.05 | 14.43 ± 6.99 | 0.070 |
| BMI (kg/m2) | 21.43 ± 1.96 | 22.07 ± 1.70 | 0.239 |
| FSH (U/L) | 7.93 ± 3.09 | 7.25 ± 2.87 | 0.175 |
| LH (U/L) | 4.92 ± 3.42 | 4.74 ± 2.87 | 0.740 |
| E2 (pg/ml) | 49.43 ± 26.92 | 43.73 ± 31.25 | 0.232 |
| PRL (ng/ml) | 14.46 ± 6.56 | 15.21 ± 9.03 | 0.551 |
| Testosterone (ng/ml) | 0.45 ± 0.26 | 0.47 ± 0.36 | 0.645 |
| FBG (mmol/L) | 4.89 ± 0.41 | 5.11 ± 0.64 | 0.014a |
| 2-h BG (mmol/L) | 5.32 ± 0.90 | 6.88 ± 1.68 | 0.006b |
| FI (mU/L) | 60.17 ± 27.80 | 97.09 ± 58.41 | 0.000b |
| 2-h Insulin (mU/L) | 174.08 ± 83.28 | 545.17 ± 230.38 | 0.000b |
| HOMA-IR | 1.90 ± 0.93 | 3.23 ± 2.38 | 0.000b |
| HOMA-M120 | 6.09 ± 3.27 | 21.85 ± 8.45 | 0.000b |
| Sc-Hypothyroidism (%) | 20.62 | 37.93 | 0.019a |
| HCY | 7.26 ± 2.28 | 7.15 ± 2.67 | 0.814 |
| 25-OH-VD3 | 18.93 ± 8.30 | 18.86 ± 5.40 | 0.957 |
BMI, Body mass index; FSH, follicle stimulating hormone; LH, luteinizing hormone; E2, estradiol; PRL, prolactin; FBG, fasting blood glucose;2-h BG, 2 hour blood glucose; FI, fasting insulin; HOMA-IR, homeostasis- model assessment of insulin resistance; HOMA-M120 was calculated as (post-load 2-hour insulin uIU/ml x post-load 2-hour glucose mmol/l)/22.5.Sc-Hypothyroidism, subclinical hypothyroidism.
P < 0.05 was considered statistically significant; aP < 0.05, bP < 0.01.