TABLE 2.

Outcome of primary objective examining risk of dementia within patients diagnosed with rheumatoid arthritis (RA) identified from the Optum and MDCR databases

			TNFI				Methotrexate				Calibrated results
Database	Sample	Outcome	N at risk	Person‐years	N with outcome	IR per 1000 py	N at risk	Person‐years	N with outcome	IR per 1000 py	HR	95% CI Lower	95% CI Upper
Optum	RA patients	Dementia	8925	19,753	124	6.3	8925	19,542	124	6.3	0.69	0.45	1.05
MDCR	RA patients	Dementia	2125	5641	73	12.9	2125	6211	85	13.7	1.14	0.66	1.96

Abbreviations: RA, rheumatoid arthritis; TNFI, TNF‐α inhibitor; IR, incidence rate; py, person‐years; HR, hazard ratio; CI, confidence interval.