Table 2.
Unadjusted univariate logistic regression analysis for death as outcome after COVID-19 for the entire cohort of KTxs, and by waves
| All patients (n = 182) |
First wave (n = 33) |
Second wave (n = 149) |
||||
|---|---|---|---|---|---|---|
| OR [95% CI] | p value | OR [95% CI] | p value | OR [95% CI] | p value | |
| Age (years) | 1.06 [1.02–1.11] | 0.006 | 1.08 (0.98–1.18) | 0.114 | 1.06 (1.01–1.11) | 0.030 |
| Male | 0.93 [o.41–2.08] | 0.855 | 0.53 (0.1–2.88) | 0.459 | 1.04 (0.41–2.65) | 0.932 |
| BMI (kg/m3) | 1.02 [0.92–1.12] | 0.716 | 1.01 (0.8–1.27) | 0.933 | 1.1 (0.91–1.13) | 0.798 |
| Months after transplant | 1.00 [0.997–1.01] | 0.324 | 1 (0.99–1.01) | 0.775 | 1 (1–1.01) | 0.311 |
| CCI | ||||||
| 2 (reference) | 0.031 | 0.156 | 0.101 | |||
| 3 or 4 | 3.66 [1.30–10.32] | 0.014 | 4.23 (0.43–41.87) | 0.217 | 3.49 (1.09–11.17) | 0.036 |
| 5+ | 4.52 [1.23–16.61] | 0.023 | 22 (0.94–515.87) | 0.055 | 3.31 (0.74–14.76) | 0.116 |
| eGFR at baseline | 0.95 [0.93–0.97] | <0.001 | 0.94 (0.89–0.99) | 0.029 | 0.95 (0.92–0.97) | <0.001 |
| Obesity | 1.01 [0.38–2.69] | 0.985 | 0.45 (0.05–4.46) | 0.497 | 1.24 (0.42–3.7) | 0.694 |
| Hypertension | 4.54 [1.03–19.96] | 0.045 | 807,737,446.81 (0–0) | 0.999 | 2.86 (0.63–12.98) | 0.172 |
| Diabetes | 1.18 [0.50–2.77] | 0.712 | 5.25 (0.91–30.22) | 0.063 | 0.72 (0.25–2.09) | 0.549 |
| Antiviral | ||||||
| None (reference) | 0.334 | 0.657 | 0.335 | |||
| Antiretrovirals | 2.37 [0.75–7.49] | 0.142 | 1.33 (0.19–9.27) | 0.771 | 3.07 (0.69–13.6) | 0.140 |
| Remdesivir/favipiravir | 1.28 [0.49–3.33] | 0.608 | 2.67 (0.33–21.73) | 0.360 | 1.1 (0.37–3.28) | 0.871 |
| Immunomodulatory | 0.97 [0.37–2.57] | 0.948 | 0.36 (0.06–2.15) | 0.263 | 1.26 (0.39–4.14) | 0.700 |
| Corticosteroids | 1.28 [0.59–2.80] | 0.529 | 0.42 (0.07–2.53) | 0.346 | 1.77 (0.73–4.33) | 0.209 |
| Anticoagulants | 1.95 [0.82–4.64] | 0.132 | 0.95 (0.15–5.99) | 0.954 | 2.19 (0.81–5.94) | 0.122 |
| ACE inhibitors/ARB | 1.17 [0.44–3.08] | 0.758 | 1.33 (0.13–14.01) | 0.811 | 1.08 (0.37–3.15) | 0.893 |
ACE, angiotensin-converting enzyme; ARB, angiotensin receptor blockers; CCI, Charlson comorbidity index; eGFR, estimated glomerular filtration rate; BMI, body mass index; KTx, kidney transplant recipient.