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. Author manuscript; available in PMC: 2021 Sep 20.

Published in final edited form as: Gynecol Oncol. 2020 Aug 26;159(1):101–111. doi: 10.1016/j.ygyno.2020.05.045

Fig. 3. — TWiST analyses with TOX defined as all grade ≥3 TEAEs (A: <65 years; B: 65–74 years; C: ≥75 years) and TOX defined as grade ≥2 TEAEs of nausea, vomiting, fatigue, and asthenia (D: <65 years; E: 65–74 years; F: ≥75 years), and Q-TWiST analyses by age subgroup with TOX defined as all grade ≥3 TEAEs^a (G) and as grade ≥2 TEAEs of nausea, vomiting, fatigue, and asthenia^b (H). ^aμTOX values: 0.90 (<65 years), 0.87 (65–74 years), 0.94 (≥75 years). ^bμTOX values: 0.86 (<65 years), 0.84 (65–74 years), 0.83 (≥75 years). μTOX, mean utility weight for TOX health state; CI, confidence interval; Q-TWiST, quality-adjusted time without symptoms or toxicity; TEAE, treatment-emergent adverse event; TOX, time with toxicity of treatment.

Fig. 3. — TWiST analyses with TOX defined as all grade ≥3 TEAEs (A: <65 years; B: 65–74 years; C: ≥75 years) and TOX defined as grade ≥2 TEAEs of nausea, vomiting, fatigue, and asthenia (D: <65 years; E: 65–74 years; F: ≥75 years), and Q-TWiST analyses by age subgroup with TOX defined as all grade ≥3 TEAEs^a (G) and as grade ≥2 TEAEs of nausea, vomiting, fatigue, and asthenia^b (H). ^aμTOX values: 0.90 (<65 years), 0.87 (65–74 years), 0.94 (≥75 years). ^bμTOX values: 0.86 (<65 years), 0.84 (65–74 years), 0.83 (≥75 years). μTOX, mean utility weight for TOX health state; CI, confidence interval; Q-TWiST, quality-adjusted time without symptoms or toxicity; TEAE, treatment-emergent adverse event; TOX, time with toxicity of treatment.