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. 2021 Sep 14;16:6297–6311. doi: 10.2147/IJN.S323685

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© 2021 Zhao et al.

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Natural nanoparticles (Nnps) changed the crystal form of berberine hydrochloride (BBR). Scanning electron microscopy images of BBR (A) and Nnps-BBR (B) (10,000 ×); (C) Laser confocal fluorescence microscope observation (6000 ×) of BBR powder (a), BBR solution (b), Nnps-BBR powder (c), and Nnps-BBR solution (d); (D) Differential scanning calorimetry images of BBR, Nnps, the physical mixture of Nnps and BBR (Mix), and Nnps-BBR complex; (E) Powder X-ray diffraction images of BBR, Nnps, physical mixture of Nnps and BBR (Mix), and Nnps-BBR complex.