Figure 5.
Concentration-time curves of berberine hydrochloride (BBR) in the systemic circulation (A), portal vein (B), and livers (C) of mice receiving 200 mg/kg oral BBR, the complex of the natural nanoparticles (Nnps) and BBR (Nnps-BBR), and Coptidis Rhizoma extract, which all contained the corresponding dosage of BBR (Mean ± SD, n = 6).