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. 2021 Sep 20;21:504. doi: 10.1186/s12935-021-02180-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — LINC01605 is highly expressed in patients with CC. A the heatmap of the top 20 differentially expressed lncRNAs in GSE97300, GSE84983, GSE110715 and GSE70880, GSE75970 gene expression microarrays. B expression of LINC01605 in cancer and ADJ tissues of 134 CC patients were detected by RT-qPCR. C expression of LINC01605 in the TCGA-COAD database. D Kaplan–Meier analysis of the correlation between the expression of LINC01605 and the survival of COAD patients. E Kaplan–Meier analysis of the correlation between the expression of LINC01605 and the survival rate of 134 CC patients. F LINC01605 expression difference in tumor tissues of patients with recurrence or not measured using RT-qPCR. G analysis of the correlation between the expression of LINC01605 and the clinical phenotype of 134 patients. H Spearman’s correlation analysis of LINC01605 expression with the levels of CC markers CEA and CA199 in patients’ serum. I Cibersort analysis of the correlation between LINC01605 expression and immune cell infiltration in tumor tissues of COAD patients. Error bars represent means ± SD for three independent experiments (*p < 0.05, **p < 0.01 and ***p < 0.001, ns, not significant. paired or unpaired t test, one-way ANOVA, followed by Tukey’s multiple comparison)