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. 2021 Sep 20;21:504. doi: 10.1186/s12935-021-02180-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — LINC01605 is regulated by the SMYD2-EP300 complex. A staining of H3K4me3 and H3K27ac in cancer and ADJ tissues of CC patients examined using immunohistochemistry. B Spearman’s correlation analysis of the staining intensity of H3K27ac or H3K4me3 with the expression of LINC01605 in CC tissues. C H3K27ac or H3K4me3 recruitment levels of LINC01605 promoter in tumor and ADJ tissues of four CC patients measured using ChIP-qPCR. D R TFBS package and the JASPAR website prediction of regulatory factors that bind to the LINC01605 promoter. E expression of SMYD2 and EP300 in TCGA-COAD database; F SMYD2 or EP300 recruitment levels of LINC01605 promoter in tumor and ADJ tissues of four CC patients examined using ChIP-qPCR; G the subcellular localization of SMYD2 and EP300 in CC tissues detected using fluorescence co-localization assay. Error bars represent means ± SD for three independent experiments (**p < 0.01, two-way ANOVA, followed by Tukey’s multiple comparison)