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. 2021 Sep 19;40:292. doi: 10.1186/s13046-021-02091-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — TAGLN regulates ovarian cancer progression through RhoA/ROCK pathway. A Western blot analyzed TAGLN, ROCK1, ROCK2 and RhoA of cells transfected with siControl or TAGLN siRNA. GAPDH was used as a loading control. B Western blot analyzed TAGLN, ROCK1, ROCK2 and RhoA of cells transfected with vector or TAGLN plasmid. GAPDH was used as a loading control. C-D Representative images (C) and scores (D)of IHC staining for ROCK1, ROCK2 and RhoA from mice bearing SK-OV-3 cells transfected with sh-control or sh-TAGLN lentivirus (*P < 0.05). Scale bar: 20 μm. E-F Migratory (E) and invasive (F) ability of cells treated with Rhosin or Y27632 after transfected with control vector or TAGLN plasmid (*P < 0.05, **P < 0.01, ****P < 0.0001). G A graphical illustration of the molecular signaling events involved in stiffness-regulated OC progression. TAGLN mediated stiffness-regulated OC progression through RhoA/ROCK pathway