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. 2021 Sep 6;9:671631. doi: 10.3389/fped.2021.671631

Table 2.

Risk of neurodevelopmental disorders in individuals diagnosed with feeding and eating disorder compared with age and sex matched controls (n = 21,637).

Individuals with FED Matched controls Unadjusted
HR (95% CI)
Adjusted#
HR (95% CI)
No. diagnosed Incidence rate* No. diagnosed Incidence rate*
All combined
    Emotional/behavioral disorder 175 8.92 612 3.03 2.98 (2.52–3.52) 2.78 (2.34–3.31)
    Attention-deficit/hyperactivity disorder 68 3.33 369 1.82 1.85 (1.43–2.40) 1.74 (1.33–2.26)
    Autism spectrum disorder 84 4.12 261 1.28 3.24 (2.53–4.14) 3.05 (2.36–3.94)
    Intellectual disability 60 2.89 77 0.38 7.67 (5.47–10.75) 6.38 (4.48–9.11)
Boys
    Emotional/behavioral disorder 90 9.80 405 4.26 2.33 (1.86–2.93) 2.16 (1.70–2.73)
    Attention-deficit/hyperactivity disorder 43 4.49 254 2.64 1.72 (1.24–2.37) 1.62 (1.17–2.25)
    Autism spectrum disorder 54 5.63 197 2.04 2.77 (2.05–3.74) 2.58 (1.88–3.53)
    Intellectual disability 32 3.25 53 0.54 5.74 (3.70–8.92) 4.94 (3.10–7.86)
Girls
    Emotional/behavioral disorder 85 8.14 207 1.94 4.26 (3.31–5.48) 4.05 (3.12–5.25)
    Attention-deficit/hyperactivity disorder 25 2.31 115 1.07 2.18 (1.41–3.36) 2.01 (1.29–3.15)
    Autism spectrum disorder 30 2.78 64 0.60 4.70 (3.04–7.24) 4.54 (2.90–7.12)
    Intellectual disability 28 2.56 24 0.22 12.12 (7.02–20.92) 9.73 (5.48–17.26)

FED, feeding and eating disorders; No., number; HR, hazard ratio; CI, confidence interval;

*

incident rate per 1,000 person-years;

#

adjusted for parity, parental age, maternal education, maternal origin, maternal cohabitation at birth, maternal smoking status during early pregnancy, parental history of psychiatric disorders before childbirth, and pregnancy complications including diabetes and pre-eclampsia.