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In vivo and in vitro inhibition of RORC. (A) Study design of in vivo prophylactic treatment (B) Dose response effect of in vitro RORC inhibition on frequencies of IL-17+ yd T cells. (C) Relative expression of genes >2fold differentially regulated in vehicle vs RORCi treated rats. (D) Gene expression from the selected genes, IL-17A, IL-22, IL-17F and IL-13 was confirmed by regular qPCR. Data are individual data points and median.
