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. 2021 Sep 6;12:699987. doi: 10.3389/fimmu.2021.699987

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Copyright © 2021 van Tok, Mandour, Wahle, Labadia, van de Sande, Nabozny, Baeten and van Duivenvoorde

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RORC antagonist accelerated spondylitis and arthritis development and increased arthritis severity. (A) Incidence of spondylitis and arthritis in vehicle vs RORCi treated rats (B) disease severity, displayed as arthritis score and hind paw swelling in vehicle vs RORCi treated rats. Data are mean +/- SEM.