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. 2021 Sep 6;12:699987. doi: 10.3389/fimmu.2021.699987

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Copyright © 2021 van Tok, Mandour, Wahle, Labadia, van de Sande, Nabozny, Baeten and van Duivenvoorde

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased histological pathology in RORC inhibitor treated rats. Peripheral and axial joints were semi-quantitatively scored (0–3) for inflammation, destruction, new bone formation and hypertrophic chondrocytes.