TABLE 1.

Patient characteristics

Characteristics	All	Age < 70 years	Age ≥ 70 years	P‐value
	N = 86	N = 65	N = 21
Age, years, median (range)	64 (32‐77)	61 (32‐69)	74 (70‐77)
Sex				.28
Male	75 (87.2%)	55 (84.6%)	20 (95.2%)
Female	11 (12.8%)	10 (15.4%)	1 (4.8%)
Primary site				.49
Hypopharynx	23 (26.7%)	15 (23.1%)	8 (38.1%)
Oral cavity	21 (24.4%)	16 (24.6%)	5 (23.8%)
Oropharynx	15 (17.4%)	11 (16.9%)	4 (19.0%)
Larynx	12 (13.9%)	11 (16.9%)	1 (4.8%)
Nasopharynx	5 (5.8%)	5 (7.7%)	0 (0.0%)
Others	10 (11.6%)	7 (10.7%)	3 (14.3%)
ECOG PS				.31
0	47 (54.6%)	38 (58.4%)	9 (42.9%)
≥1	39 (45.4%)	27 (41.6%)	12 (57.1%)
Extent of disease				.34
Locoregional recurrence	15 (17.4%)	13 (20.0%)	2 (9.5%)
Metastatic disease	71 (82.6%)	52 (80.0%)	19 (90.5%)
Metastatic sites
Lung	53 (61.6%)	36 (55.4%)	17 (81.0%)	.04
Distant lymph node	22 (25.5%)	19 (29.2%)	3 (14.3%)	.25
Bone	10 (11.6%)	9 (13.8%)	1 (4.8%)	.44
Liver	5 (5.8%)	4 (6.2%)	1 (4.8%)	1.00
Target lesions	62 (72.1%)	49 (75.4%)	13 (61.9%)	.27
Prior surgery	53 (61.6%)	38 (58.5%)	15 (71.4%)	.32
Prior radiotherapy	50 (58.1%)	40 (61.5%)	10 (47.6%)	.31
Prior chemotherapy with cisplatin	22 (25.6%)	19 (29.2%)	3 (14.3%)	.25
Serum creatinine (mg/dl), median (range)	0.76 (0.33‐1.48)	0.73 (0.33–1.48)	0.82 (0.40‐1.16)	.12
CCr (Cockcroft‐Gault Equation) (ml/min), median (range)	80.7 (41.9‐151.3)	86.2 (46.8‐151.3)	62.4 (41.9‐94.8)	.001
Smoking history				.40
None	19 (22.1%)	14 (21.5%)	5 (23.8%)
<20 pack‐year	19 (22.1%)	17 (26.2%)	2 (9.5%)
≥20 pack‐year	47 (54.7%)	33 (50.8%)	14 (66.7%)
Unknown	1 (1.2%)	1 (1.5%)	0 (0.0%)
Alcohol use				.17
None	29 (33.7%)	23 (35.4%)	6 (28.6%)
Occasional use	5 (6.2%)	4 (6.2%)	1 (4.8%)
<2 drinks/day	9 (10.5%)	4 (6.2%)	5 (23.8%)
≥2 drinks/day	37 (43.0%)	28 (43.1%)	9 (42.9%)
Unknown	6 (7.0%)	6 (9.2%)	0 (0.0%)

Abbreviations: CCr, creatinine clearance; ECOG PS, Eastern Cooperative Oncology Group performance status.