TABLE 3.

Adverse events related with the EXTREME regimen

	Any grade				Grade 3/4
	All	Age < 70	Age ≥ 70		All	Age < 70	Age ≥ 70
	N = 86	N = 65	N = 21	P‐value	N = 86	N = 65	N = 21	P‐value
Hematological
Leukopenia	61 (70.9%)	48 (73.8%)	13 (61.9%)	.41	31 (36.0%)	25 (38.5%)	6 (28.6%)	.45
Neutropenia	63 (73.3%)	49 (75.4%)	14 (66.7%)	.57	36 (41.9%)	30 (46.2%)	6 (28.6%)	.21
Anemia	74 (86.0%)	57 (87.7%)	17 (81.0%)	.48	2 (2.3%)	2 (3.1%)	0 (0.0%)	1.00
Thrombocytopenia	47 (54.7%)	35 (53.8%)	12 (57.1%)	1.00	2 (2.3%)	1 (1.5%)	1 (4.8%)	.43
Non‐hematological
Nausea	51 (59.3%)	44 (67.7%)	7 (33.3%)	.01	7 (8.1%)	6 (9.2%)	1 (4.8%)	1.00
Vomiting	6 (7.0%)	6 (9.2%)	0 (0.0%)	.33	0 (0.0%)	0 (0.0%)	0 (0.0%)
Anorexia	62 (72.1%)	46 (70.8%)	16 (76.2%)	.78	6 (7.0%)	5 (7.7%)	1 (4.8%)	1.00
Diarrhea	16 (18.6%)	10 (15.4%)	6 (28.6%)	.20	0 (0.0%)	0 (0.0%)	0 (0.0%)
Stomatitis	28 (32.6%)	20 (30.8%)	8 (38.1%)	.60	0 (0.0%)	0 (0.0%)	0 (0.0%)
Rash acneiform	66 (76.7%)	49 (75.4%)	17 (81.0%)	.77	4 (4.7%)	4 (6.2%)	0 (0.0%)	.57
Febrile neutropenia					2 (2.3%)	1 (1.5%)	1 (4.8%)	.43
Creatinine increased	12 (13.9%)	10 (15.4%)	2 (9.5%)	.72	0 (0.0%)	0 (0.0%)	0 (0.0%)
Peripheral sensory neuropathy	25 (29.1%)	20 (30.8%)	5 (23.8%)	.59	1 (1.2%)	1 (1.5%)	0 (0.0%)	1.00