Table 2.
Meta-analysis of the association between total fiber intake and genera and species with concomitantly increasing or decreasing abundance in NCI and NYU study populations
| Phylum; Class; Order; Family; Genus; Species | NCI | NYU | Meta FC |
Meta 95% CI |
Meta p |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Base Mean |
FC | p- value |
p-adj | Base Mean |
FC | p- value |
p-adj | ||||
| Genus Level | |||||||||||
| Actinobacteria; Actinobacteria; Actinomycetales; Actinomycetaceae; Actinomyces | 2.16 | 0.884 | 0.003 | 0.110 | 0.75 | 0.969 | 0.130 | 0.454 | 0.951 | (0.917-0.986) | 0.0015 |
| Bacteroidetes; Bacteroidia; Bacteroidales; [Odoribacteraceae]; Odoribacter | 0.68 | 0.995 | 0.916 | 0.967 | 10.88 | 0.946 | 0.004 | 0.176 | 0.953 | (0.921-0.987) | 0.0318 |
| Firmicutes; Clostridia; Clostridiales; Clostridiaceae; SMB53 | 0.62 | 1.035 | 0.443 | 0.913 | 0.88 | 1.045 | 0.029 | 0.391 | 1.044 | (1.007-1.082) | 0.0360 |
| Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospira | 31.63 | 1.042 | 0.279 | 0.875 | 163.91 | 1.026 | 0.091 | 0.406 | 1.028 | (1.000-1.057) | 0.0497 |
| Firmicutes; Clostridia; Clostridiales; Ruminococcaceae; Faecalibacterium | 230.42 | 1.030 | 0.367 | 0.913 | 549.73 | 1.025 | 0.078 | 0.391 | 1.025 | (1.000-1.051) | 0.0589 |
| Firmicutes; Clostridia; Clostridiales; Ruminococcaceae; Oscillospira | 22.58 | 0.973 | 0.386 | 0.913 | 85.60 | 0.983 | 0.079 | 0.391 | 0.982 | (0.965-1.000) | 0.0630 |
| Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus | 55.61 | 0.957 | 0.299 | 0.875 | 57.84 | 0.985 | 0.443 | 0.797 | 0.980 | (0.947-1.015) | 0.2023 |
| Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Anaerostipes | 5.92 | 1.007 | 0.859 | 0.967 | 10.66 | 1.018 | 0.287 | 0.641 | 1.016 | (0.986-1.048) | 0.3772 |
| Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Dorea | 104.47 | 1.022 | 0.418 | 0.913 | 65.24 | 1.004 | 0.666 | 0.797 | 1.006 | (0.988-1.025) | 0.3815 |
| Firmicutes; Clostridia; Clostridiales; Veillonellaceae; Phascolarctobacterium | 18.58 | 1.009 | 0.832 | 0.967 | 34.43 | 1.012 | 0.558 | 0.797 | 1.012 | (0.975-1.049) | 0.5709 |
| Firmicutes; Clostridia; Clostridiales; Veillonellaceae; Dialister | 16.99 | 0.984 | 0.713 | 0.967 | 25.15 | 0.994 | 0.780 | 0.869 | 0.992 | (0.955-1.031) | 0.6476 |
| Proteobacteria; Betaproteobacteria; Burkholderiales; Alcaligenaceae; Sutterella | 4.32 | 1.009 | 0.849 | 0.967 | 85.39 | 1.008 | 0.653 | 0.797 | 1.008 | (0.976-1.040) | 0.6502 |
| Actinobacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae; Bifidobacterium | 84.01 | 1.001 | 0.973 | 0.973 | 90.68 | 1.004 | 0.850 | 0.925 | 1.003 | (0.967-1.041) | 0.8745 |
| Actinobacteria; Coriobacteriia; Coriobacteriales; Coriobacteriaceae; Eggerthella | 6.18 | 0.985 | NA | NA | 2.09 | 0.990 | 0.631 | 0.797 | 0.989 | (0.951-1.028) | NA |
| Species Level | |||||||||||
| Firmicutes; Erysipelotrichi; Erysipelotrichales; Erysipelotrichaceae; [Eubacterium]; dolichum | 7.70 | 0.933 | 0.198 | 0.770 | 3.34 | 0.963 | 0.122 | 0.540 | 0.958 | (0.917-1.000) | 0.045 |
| Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; uniformis | 32.05 | 0.948 | 0.202 | 0.770 | 305.56 | 0.972 | 0.128 | 0.540 | 0.968 | (0.936-1.001) | 0.048 |
| Firmicutes; Clostridia; Clostridiales; Ruminococcaceae; Faecalibacterium; prausnitzii | 230.05 | 1.032 | 0.354 | 0.884 | 540.38 | 1.024 | 0.103 | 0.540 | 1.026 | (0.999-1.053) | 0.070 |
| Firmicutes; Clostridia; Clostridiales; Ruminococcaceae; Ruminococcus; bromii | 24.12 | 0.966 | 0.489 | 0.951 | 1.65 | 0.969 | 0.161 | 0.578 | 0.968 | (0.930-1.008) | 0.138 |
| Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Dorea; formicigenerans | 1.92 | 1.033 | 0.447 | 0.915 | 20.11 | 1.018 | 0.323 | 0.730 | 1.020 | (0.988-1.054) | 0.216 |
| Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; ovatus | 5.59 | 0.987 | 0.790 | 0.951 | 12.37 | 0.982 | 0.309 | 0.730 | 0.982 | (0.950-1.016) | 0.363 |
| Actinobacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae; Bifidobacterium; adolescentis | 38.42 | 1.007 | 0.898 | 0.951 | 75.56 | 1.002 | 0.932 | 0.964 | 1.003 | (0.959-1.049) | 0.880 |
| Actinobacteria; Coriobacteriia; Coriobacteriales; Coriobacteriaceae; Eggerthella; lenta | 6.14 | 0.984 | NA | NA | 1.99 | 0.986 | 0.613 | 0.839 | 0.986 | (0.939-1.035) | NA |
Relationship between higher quartiles of fiber intake and differential taxon abundance was evaluated using negative binomial generalized linear models in the DESeq2 package in R. Models were adjusted for age, sex, race, categorical BMI and cigarette smoking status. This table reports results from a taxonomy-based meta-analysis to evaluate for genera and species with concomitantly higher or lower abundance by fiber intake (as determined by fold change [FC]) in both study populations.