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RB1 promoter CpG methylation profile of a Pr−/- retinoblastoma (1706) homozygous for the promoter variant c.-212 G > T spanning CpGs −627-+77 (underlined). (a) pie chart summary of RB1 promoter DNA methylation of CpGs that include putative CTCF binding site, core promoter (CP), coding and untranslated exons; (b) bar chart summary of 1706 CpG methylation of RB1 upstream region −627 to+77; (c) bar chart summary of normal peripheral blood DNA.
