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. 2021 Sep 6;11:724435. doi: 10.3389/fonc.2021.724435

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Copyright © 2021 Li, Liu, Liu, Yang, Xu, Wang, Jiang, Liu, Wang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Down-regulation of GNA15 inhibited cell proliferation and colony formation in AML cells. The efficiency of GNA15 knockdown in the Kasumi-1 and SKNO-1 cell lines was verified by (A, B) real-time quantitative polymerase chain reaction and (C, F) Western blot, respectively. (D, E) Cell proliferation was detected by the CCK-8 assay in Kasumi-1 and SKNO-1. (G–I) The colony formation of GNA15-CTRL and GNA15-KD in Kasumi-1. CTRL, control; KD, knockdown; *P < 0.05 compared with CTRL cells; **P < 0.01 compared with CTRL cells; ***P < 0.001 compared with CTRL cells; Error bars indicate the standard deviation.