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. 2007 Jul 18;2007(3):CD002739. doi: 10.1002/14651858.CD002739.pub3

Stelmach 2008.

Methods RCT, double‐blind, parallel study.
Regular medications stopped for 4 weeks.
Concomitant treatment: bronchodilators allowed ( except < 6 hours of exercise test).
Exercise test: treadmill to achieve heart rate of 95% maximum predicted for age.
Participants N= 39. Age 6‐18 years. Stable atopic asthmatics who were on inhaled budesonide ( average 400 mcg/day) and montelukast or long‐acting bronchodilator.
Inlcusion criteria: Clinical diagnosis of asthma of at least 6 months, resting FEV1 or at least 70% or more and reduction in FEV1 of 20% or more after exercise.
Exclusion criteria: recent upper respiratory tract infection (including sinusitis), previous intubation, or asthma hospitalization during 3 months before pre‐study visit. Patients with significant co‐morbidities and patients using beta‐blocker, oral corticosteroids or immunotherapy were also excluded.
Interventions In random order: Budesonide turbuhaler 100mcg bid or placebo inhalers for 4 weeks.
Other treatment arms studied were: budesonide + formoterol ( 4.5 mcg bid) inhaler; Budesonide + montelukast ( 5 mg/day or 10mg /day depending on age ), montelukast ( 5mg/day or 10 mg/day depending on age )
Outcomes Maximal percentage fall in FEV1 after exercise was measured. The area under the curve (AUC) for the percentage fall in FEV1 from exercise over the 20 min period was calculated.
Notes Jadad score 4
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk information not available