| Methods |
RCT, double‐blind, parallel study
Drop‐out: 1 due to change in employment, 5 due to exacerbations of asthma
Concomitant treatment: short‐acting beta agonist( stopped 8 hours before test)
Exercise: treadmill; 6 min; to achieve 90% maximum heart rate |
| Participants |
N=40,28m,12f. Age: 18‐45 (median 28). Inclusion criteria: Drop in FEV1 post exercise >20%, asthma for 2 years or more, FEV1% predicted > 50%, PD20 of 4micromol or less ,PV20 of 640L or less, not current smoker and had never smoked more than 10 cigarettes a day for 2 years, be having no treatment other than an inhaled beta2 agonist, stable asthma, no chest infection for at least 6 weeks before entry into the study. skin prick tests were performed in and 37 of the 40 subjects had a positive response( weal of more than 2 mm) to at least one allergen. |
| Interventions |
In random order: Budesonide inhaler 800 mcg bid or placebo inhaler ( with MDI and spacer) for 6 weeks |
| Outcomes |
FEV1 response to histamine, exercise and Eucapnic Voluntary Hyperventilation |
| Notes |
Jadad score 3 |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Unclear risk |
Information not available |
