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. 2021 Jun 7;17(1):185–193. doi: 10.4103/1673-5374.314312

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Sustained and prolonged 4-HNE load in a mouse model of SCI.

Western blot (A) and densitometry (B) from the spinal cord of traumatic penumbra (caudal-rostral areas) showing sustained increased levels of 4-HNE in SCI groups compared with Sham (30 days) at different time points (24 hours, 48 hours, 72 hours, 30 days) in a mouse model of SCI. Data are presented as the mean ± SD (n = 5). ***P < 0.001, vs. Sham (one-way analysis of variance with Tukey’s post hoc test). 4-HNE: 4-Hydroxy-trans-2-nonenal; SCI: spinal cord injury.