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. 2021 Jun 7;17(1):185–193. doi: 10.4103/1673-5374.314312

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Copyright: © Neural Regeneration Research

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Alda-1 treatment decreases 4-HNE load and enhances the activity of ALDH2 in the acute phase (72 hours) of a mouse model of SCI.

Two different doses of Alda-1 were used to show that only a 10 mg/kg dose effectively reduced 4-HNE load. Western blot (A) and densitometry (B) from the spinal cord of traumatic penumbra (caudal-rostral areas). Measurement of ALDH2 activity (C). Western blot of ALDH2 (D) and densitometry (E). Data are presented as the mean ± SD (n = 7). **P < 0.01, ***P < 0.001, vs. Sham; ++P < 0.01, +++P < 0.001, vs. Alda-1 (one-way analysis of variance with Tukey’s post hoc test). 4-HNE: 4-Hydroxy-trans-2-nonenal; Alda-1: N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide; ALDH2: aldehyde dehydrogenase 2; ns: not significant; SCI: spinal cord injury.