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. 2021 Jun 7;17(1):178–184. doi: 10.4103/1673-5374.314321

Figure 5.

Figure 5

PGSF reverses the glutamate-induced regulation of NR2A and NR2B expression in cultured hippocampal neurons.

(A, B) Glutamate downregulated the expression of NR2A subunits and upregulated the expression of NR2B subunits in a time-dependent manner. (C, D) The glutamate-induced downregulation of NR2A and upregulation of NR2B was reversed by co-administration of PGSF. Data are shown as the mean ± SEM. The experiment was repeated four times. **P < 0.01, ***P < 0.001 (one-way analysis of variance followed by Dunnett’s post hoc test). Original data for Figure 5 are shown in Additional file 6. Ctrl: Control; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; Glu: glutamate; MK801: (5S,10R)-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate, an N-methyl-D-aspartate receptor antagonist; PGSF: polygalasaponin F.