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. 2021 Jun 7;17(1):194–202. doi: 10.4103/1673-5374.314323

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Copyright: © Neural Regeneration Research

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BMSC-EXOs preserve blood-spinal cord barrier integrity and reduce edema post-SCI.

(A) Macroscopic images of Evans blue extravasation photographed at 3 dpi. The rectangle indicates the location of the damage. (B) Fluorescence microscopy images of Evans blue leakage at 3 dpi. Scale bar: 1 mm. (C) IVIS images of spinal cord stripped from the spine at 3 dpi. Compared with the Sham and EXO groups, the SCI group showed severe injury with higher EB content in A, and stronger fluorescence intensity in B and C. Exosome treatment reversed these changes. The rectangle indicates the location of the damage. (D) Quantitative analysis of Evans blue leakage. (E) Quantification of spinal cord water content at 3 dpi. Data are expressed as the mean ± SD (n = 6). *P < 0.05 (Student’s t-test). BMSC-EXO: Bone mesenchymal stem cell-derived exosome; dpi: days post injury; EXO: exosome; IVIS: In Vivo Imaging System; SCI: spinal cord injury.