Table 4.

List of the dosage, pharmacokinetics and side-effects of commonly prescribed TCAs and SSRIs for PE

Drug	Dosage, mg	Metabolism	Half life	Side-effects
Clomipramine [,79]	25	CYP2C19, CYP3A4, CYP1A2	10–70 h	Manic episode in both bipolar and unipolar disorders. Anticholinergic side-effects: dry mouth, blurring of vision, constipation, urinary retention and aggravation of narrow-angle glaucoma. Cardiac side-effects including tachycardia, flattened T waves, prolonged QT intervals, and depressed ST segments
Fluoxetine [161,162]	20–40 daily	CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4	1–4 days	Dizziness, dry mouth, nausea, constipation, weight gain, insomnia, tremors, prolonged QT interval, light headedness, confusion, agitation, sexual dysfunction
Citalopram [163,164]	20	CYP2C19, CYP2D6, CYP3A4	35 h
Escitalopram [165–168]	10	CYP2C19, CYP3A4	35 h
Sertraline [79]	25–50	CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4	26 h
Paroxetine [73,74,169]	20	CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4	Variable depends on dose
Fluvoxamine [79,170]	50–300	CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4	15 h and 17 to 22 h
Dapoxetine [82,171]	30 or 60	CYP2D6, CYP3A4	1.4 and 20 h