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. 2021 Sep 6;12:702392. doi: 10.3389/fphar.2021.702392

FIGURE 2.

FIGURE 2

Vascular activities of structurally different ET-CORMs on mesenteric arteries. (A) Effect of rac- 1 (rac-1 2*10–4 M) and of DMSO (control) on vessel tension induced by 10–6 M methoxamine in endothelium-intact arteries. (repeated measures ANOVA, n = 5, p < 0.05). (B) Effect of rac- 1 (rac- 1 2*10–4 M) and of DMSO (control) on vessel tension induced by 10–6 M methoxamine in endothelium-denuded arteries. (repeated measures ANOVA, n = 5, p < 0.05). (C) Effect of rac- 4 (rac- 4 10–5 M) and of DMSO (control) on vessel tension induced by 10–6 M methoxamine in endothelium-intact arteries. (repeated measures ANOVA, n = 5, p < 0.05). (D) Effect of rac- 4 (rac- 4 10–5 M) and of DMSO (control) on vessel tension induced by 10–6 M methoxamine in endothelium-denuded arteries. (repeated measures ANOVA, n = 5, p < 0.05). (E) Effect of rac- 8 (rac- 8 2*10–4 M) and of DMSO (control) on vessel tension induced by 10–6 M methoxamine in endothelium-intact arteries. (repeated measures ANOVA, n = 5, p = 0.60). (F) Effect of rac-8 (rac- 8 2*10–4 M) and of DMSO (control) on vessel tension induced by 10–6 M methoxamine in endothelium-denuded arteries. (repeated measures ANOVA, n = 5, p = 0.06).