TABLE 2.
Combination of Kv channel inhibitors used for leaving only a particular channel available.
| Nr. | Combination of potassium channel inhibitorsa | Available channel | Blocked channel |
|---|---|---|---|
| 1 | Iberiotoxin, XE991, STTX, Glibenclamid, BaCl2 | Kv1 | BK, Kv7, Kv2, Kir6, Kir2 |
| 2 | Iberiotoxin, XE991, DPO-1, Glibenclamid, BaCl2 | Kv2 | BK, Kv7, Kv1, Kir6, Kir2 |
| 3 | Iberiotoxin, DPO-1, STTX, Glibenclamid, BaCl2 | Kv7 | BK, Kv1, Kv2, Kir6, Kir2 |
| 4 | XE991 | BK, Kv1, Kv2, Kir6, Kir2 | Kv7 |
a
Concentration used: Iberiotoxin (BK) 0.1 µM (Galvez et al., 1990); XE991 (Kv7) 3 µM (Greenwood and Ohya, 2009; Zavaritskaya et al., 2020); DPO-1 (Kv1) 1 µM (Lagrutta et al., 2006; Tsvetkov et al., 2016); Stromatoxin (STTX) (Kv2) 0.1 µM (Escoubas et al., 2002); BaCl2 (Kir2) 30 µM (Schubert et al., 2004); Glibenclamide (Kir6) 1 µM (Schubert et al., 1997).