Table 1.
Demographics of the study population
| Baseline | Follow‐up | Raw p‐value | Adjusted p‐value | |
|---|---|---|---|---|
| Number of participants (N) | 145 | ‐ | ‐ | |
| Follow‐up time in months (range) | 22 (15–32) | ‐ | ‐ | |
| Sex, female N (%) | 78 (54%) | ‐ | ‐ | |
| Age (years) | 68.6 (±6.3) | 70.5 (±6.2) | ‐ | ‐ |
| BCVA (LogMAR) | 0.02 (±0.10) | 0.04 (±0.16) | ‐ | ‐ |
| IOP (mmHg) | 14.2 (±2.6) | 15.6 (±2.5) | ‐ | ‐ |
| Spherical Equivalent | 0.39 (±1.82) | ‐ | ‐ | |
| MMSE (median, IQR) | 29 (29–30) | 29 (28–30) | ‐ | ‐ |
| Brain amyloid status, positive N (%) | 16 (11%) | ‐ | ‐ | ‐ |
| Global BP ND of Aβ (median, IQR) | 0.120 (0.088–0.174) | ‐ | ‐ | ‐ |
| Macular layer thickness: | ||||
| Total RT inner ring (µm) | 342.5 (±15.3) | 339.4 (±15.2) | <0.001 | <0.001 |
| Total RT outer ring (µm) | 296.0 (±12.2) | 292.9 (±12.6) | <0.001 | <0.001 |
| RNFL inner ring (µm) | 22.0 (±2.0) | 22.1 (±2.1) | 0.420 | 0.840 |
| RNFL outer ring (µm) | 36.7 (±4.7) | 36.8 (±4.8) | 0.494 | 0.494 |
| GCL inner ring (µm) | 50.4 (±4.7) | 49.8 (±4.7) | <0.001 | <0.001 |
| GCL outer ring (µm) | 34.5 (±3.2) | 34.0 (±3.2) | <0.001 | <0.001 |
| IPL inner ring (µm) | 41.4 (±3.2) | 41.1 (±3.1) | <0.001 | <0.001 |
| IPL outer ring (µm) | 28.7 (±2.4) | 28.0 (±2.4) | <0.001 | <0.001 |
| Peripapillary RNFL thickness | 98.3 (±8.7) | 95.0 (±9.0) | <0.001 | <0.001 |
Data are means unless otherwise specified. p‐Values were obtained using paired samples t‐test.
Aβ = amyloid‐beta, BCVA = Best Corrected Visual Acuity (both eyes averaged), BP ND = non‐displaceable binding potential, GCL = Ganglion Cell Layer, IOP = Intra‐Ocular Pressure (both eyes averaged), IPL = Inner Plexiform Layer, IQR = inter‐quartile range, MMSE = Mini‐Mental State Examination, NA = not applicable, RNFL = Retinal Nerve Fibre Layer, RT = Retinal Thickness.
Values in bold are significant (p < 0.05).