TABLE 2.
MAD study summary of baseline subject characteristics.
| MAD demographics | |||||
|---|---|---|---|---|---|
| LTI‐291 or placebo | 3 mg LTI‐291 | 10 mg LTI‐291 | 30 mg LTI‐291 | 60 mg LTI‐291 | Placebo |
| n | 7 | 8 | 8 | 8 | 8 |
| Male/female | 7/0 | 4/4 | 4/4 | 5/3 | 6/2 |
| Age (years), mean (range) | 65.0 (57–74) | 69.4 (60–75) | 67.3 (57–74) | 65.9 (56–75) | 67.4 (52–73) |
| BMI (kg/m2), mean (range) | 24.9 (22.2–28.1) | 24.9 (21.7–29.5) | 25.4 (19.7–28.7) | 26.7 (23.1–31.9) | 26.1 (22.8–30.8) |
| Race | |||||
| Caucasian | 6 | 7 | 7 | 8 | 8 |
| Asian | 0 | 1 | 0 | 0 | 0 |
| Latino | 1 | 0 | 0 | 0 | 0 |
| Mixed | 0 | 0 | 1a | 0 | 0 |
| GBA1 wild type/mutation | 7/0 | 7/1 | 8/0 | 7/1 | 8/0 |
a
The subject of mixed race was of Dutch‐Indonesian and German‐Indonesian descent