TABLE 6.

Arithmetic means ± standard deviation of CSF concentrations of LTI‐291 and CSF:plasma ratios of the MAD study. Three CSF samples could not be obtained (due to a repeated dry tap, a refusal of a subject and an error in lab handling). MAD, multiple ascending dose; CSF, cerebrospinal fluid; SD, standard deviation

MAD (day 14) CSF pharmacokinetics
LTI‐291 dose	3 mg (n = 6)	10 mg (n = 8)	30 mg (n = 7)	60 mg (n = 7)
LTI‐291 CSF concentration (ng/mL)
Mean ± SD	1.82 ± 0.69	4.77 ± 1.40	18.2 ± 6.73	30.7 ± 7.56
Minimum, maximum	1.01, 3.08	2.51, 6.40	7.95, 26.5	19.8, 43.3
CSF:plasma concentration ratio ([ng/mL]/[ng/mL])
Mean ± SD	0.0130 ± 0.00262	0.0127 ± 0.00317	0.0134 ± 0.00414	0.0124 ± 0.00267
Minimum, maximum	0.0105, 0.0171	0.00904, 0.0175	0.00642, 0.0194	0.00947, 0.0176