Table 2.

Recommendations for the treatment of thiamine deficiency

Organization	Target group/condition	Recommendation
WHO (1999)79	Mild deficiency states (including lactating women at risk of inadequate intakes)	10 mg daily oral dose for 1 week, followed by 3–5 mg daily oral dose for 6 weeks
	Infantile thiamine deficiency (severe heart failure, convulsions, or coma)	25–50 mg IV immediately, followed by 10 mg IM daily for 10 days, then 3–5 mg daily oral dose for 6 weeks
	Critically ill adults	50–100 mg IV immediately, followed by 3–5 mg daily oral dose for 6 weeks
Royal College of Physicians (2001)120	Alcoholism	Inpatient settings: 500 mg IV thiamine, once or twice daily, for 3–5 days, followed by 50 mg oral thiamine four times daily at discharge if there is evidence of cognitive impairment Community settings: 200 mg oral thiamine four times daily, together with a B‐complex tablet containing 30 mg thiamine
European Federation of Neurological Societies (2010)67	Wernicke's encephalopathy	200 mg three times daily, preferably IV
WHO Western Pacific Region (2017)57	Infants and children with heart failure as a result of thiamine deficiency	25 mg IV and 25 mg IM, then 25 mg daily until the child can eat, followed by 10 mg oral supplementation for 2–3 weeks. Treat the mother at the same time with 100 mg two times per day for 1 month until mother can eat a more diverse diet

IM, intramuscular; IV, intravenous.