TABLE 1.

Synaptic formation

Age	Region	Molecule	Event	Promote or inhibit	Inhibition method	Measurement	Reference
P18–25	Hippocampus	DAP12	Developmental formation	Promote	Mutation	AMPAR/NMDAR ratio	Roumier et al. (2008)
15 DIV	Neuron‐microglia co‐culture	IL‐10‐IL‐10R	Developmental formation	Promote	‒	Density of spine	Lim et al. (2013)
P30, 60	Motor cortex	BDNF‐TrkB	Motor learning	Promote	Microglia‐specific knockout	Live imaging of spine turnover	Parkhurst et al. (2013)
P8–10	Sensory cortex	‒	Developmental formation	Promote	Microglial depletion Minocycline	Live imaging of spine turnover	Miyamoto et al. (2016)
10–12 wo	Olfactory bulb	CX3CR1	Adult neurogenesis	Promote	Knockout	Density of spine	Reshef et al. (2017)
6–7 wo	Hippocampus	CX3CR1	Developmental formation	Promote	Knockout	Functional connectivity Paired pulse ratio	Basilico et al. (2019)

Abbreviations: AMPAR, α‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid receptor; BDNF, brain‐derived neurotrophic factor; CX3CR1, CX3C chemokine receptor 1; DAP12, DNAX‐activating protein of 12 kDa; DIV, day in vitro; NMDAR, N‐methyl‐D‐aspartate receptor; P, postnatal day; TrkB, tropomyosin receptor kinase B; wo, week‐old.