Table 2.
Final Model Parameter Estimatesa
| Parameter | Estimate (SE) | RSE | P value | 95%CI |
|---|---|---|---|---|
| Intercept (ms) | −2.14 (0.811) | 37.9% | 0.0084 | (−3.73 to −0.552) |
| Concentration slope (ms/[ng/mL]) | 0.00214 (0.000445) | 20.8% | <0.0001 | (0.00127 to 0.00302) |
| Baseline QTcF coefficient | −0.140 (0.0378) | 27.0% | 0.0003 | (−0.214 to −0.0648) |
| Intercept BSV SD (ms) | 7.76 (0.593) | 7.64% | … | (6.69 to 9.01) |
| Residual error SD, Study A (ms) | 10.7 (0.237) | 2.21% | … | (10.3 to 11.2) |
| Ratio of residual error SD, Study A:B | 1.54 (0.0744) | 4.83% | … | (1.40 to 1.69) |
BSV, between‐subject variability; CI, confidence interval; QTcF, QT corrected using the Fridericia formula; SD, standard deviation; SE, standard error; RSE, relative standard error.
a
The marginal coefficient of determination for the model (variance explained by the fixed effects only; ie, intercept, slope, and baseline) is 0.0634; the conditional coefficient of determination (variance explained by fixed plus random effects; ie, intercept variability—a substantial component of total variability) is 0.385.