Table 3.
Absolute change in patient‐reported outcome measure tool from baseline to days 15 and 29
| Change from baseline median (95% CI) | GPB 1% vs. placebo P‐value | ||
|---|---|---|---|
| Placebo (n = 84) | GPB 1% (n = 87) | ||
| HDSS | |||
| Median (range) baseline | 4·0 (3–4) | 3·0 (2–4)a | |
| Day 15 | 0·0 (0·0 to 0·0)b, * | –1·0 (–1·0 to 0·0)c, * | 0·002 |
| Day 29 | 0·0 (0·0 to 0·0)d, * | 0·0 (–1·0 to 0·0)e, * | 0·014 |
| HidroQoL© | |||
| Median (range) baseline | 30·0 (11·0–36·0)f | 29·0 (10·0–36·0)g | |
| Day 15 | –1·0 (–2·0 to –1·0)b, * | –5·0 (–8·0 to –2·0)h, * | < 0·001 |
| Day 29 | –1·0 (–2·0 to –1·0)b, * | –6·0 (–9·0 to –4·0)c, * | < 0·001 |
| DLQI | |||
| Median (range) baseline | 15·0 (0·0–28·0)e | 14·0 (0·0–30·0) | |
| Day 15 | –2·0 (–3·0 to –1·0)b, * | –5·0 (–7·0 to –2·0)h, * | 0·002 |
| Day 29 | –3·0 (–4·0 to –1·0)b | –5·0 (–8·0 to –4·0)c | 0·003 |
CI, confidence interval; DLQI, Dermatology Life Quality Index; GPB, glycopyrronium bromide; HDSS, Hyperhidrosis Disease Severity Scale; HidroQoL, Hyperhidrosis Quality of Life Index. a n = 86; b n = 79; c n = 84; d n = 80; e n = 83; f n = 81; g n = 87; h n = 85. *P < 0·0001.